# Product Guides - [DRAGEN v4.5](https://help.dragen.illumina.com/product-guides/dragen-v4.5.md) - [Getting Started](https://help.dragen.illumina.com/product-guides/dragen-v4.5/getting-started.md) - [DRAGEN Host Software](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-host-software.md) - [DRAGEN Secondary Analysis](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-host-software/dragen-platform.md) - [DRAGEN Apps](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps.md) - [Clinical Research Workflows](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps.md) - [Common Product Features](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/common.md) - [Sample Sheets](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/common/sample-sheet-introduction.md) - [Run Planning](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/common/run-planning.md) - [Sample Sheet Creation in BaseSpace](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/common/run-planning/basespace-run-planning-tool.md) - [Custom Config Support](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/common/run-planning/custom_config.md) - [DRAGEN Server App](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/common/server.md) - [Advanced Topics](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/common/server/advanced.md) - [Data Management](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/common/server/advanced/data-storage.md) - [Illumina Connected Insights Local](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/common/server/advanced/ici-on-prem.md) - [ICA Cloud App](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/common/cloud.md) - [Variant Interpretation with Illumina Connected Insights](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/common/cloud/ici-setup.md) - [DRAGEN Heme WGS Tumor Only Pipeline](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline.md) - [Quick Start](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/quick-start.md) - [Sample Sheet Requirements](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/quick-start/sample-sheet-requirements.md) - [Templates](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/quick-start/sample-sheet-requirements/sample-sheet-templates.md) - [DRAGEN Server App](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/installation.md) - [Launching Analysis](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/installation/launching-analysis.md) - [Command Line Options](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/installation/launching-analysis/command-line-options.md) - [Local Specific Output](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/installation/launching-analysis/output.md) - [Advanced Topics](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/installation/advanced.md) - [Custom Config Support](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/installation/advanced/custom_config.md) - [ICA Cloud App](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/setup.md) - [Launching Analysis](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/setup/launching-analysis.md) - [ICA Specific Output](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/setup/launching-analysis/output.md) - [Advanced Topics](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/setup/advanced.md) - [Custom Workflow](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/setup/advanced/workflow.md) - [Custom Config Support](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/setup/advanced/custom_config.md) - [Post Processing](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/setup/advanced/post-processing.md) - [Analysis Output](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/analysis-output.md) - [Analysis Methods](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/analysis-methods.md) - [Troubleshooting](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-heme-wgs-to-pipeline/troubleshooting.md) - [DRAGEN Solid WGS Tumor Normal Pipeline](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline.md) - [Quick Start](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/quick-start.md) - [Sample Sheet Requirements](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/quick-start/sample-sheet-requirements.md) - [Templates](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/quick-start/sample-sheet-requirements/sample-sheet-templates.md) - [DRAGEN Server App](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/installation.md) - [Launching Analysis](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/installation/launching-analysis.md) - [Command Line Options](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/installation/launching-analysis/command-line-options.md) - [Local Specific Output](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/installation/launching-analysis/output.md) - [Advanced Topics](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/installation/advanced.md) - [Custom Config Support](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/installation/advanced/custom_config.md) - [ICA Cloud App](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/setup.md) - [Launching Analysis](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/setup/launching-analysis.md) - [Advanced Topics](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/setup/advanced.md) - [Custom Workflow](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/setup/advanced/workflow.md) - [Analysis Output](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/analysis-output.md) - [Analysis Methods](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/analysis-methods.md) - [Troubleshooting](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-apps/dragen-solid-wgs-tn-pipeline/troubleshooting.md) - [DRAGEN Germline Enrichment ICA App](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-germline-enrichment-ica-app.md) - [DRAGEN Enrichment BSSH App](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-enrichment-bssh-app.md) - [DRAGEN Germline Enrichment from BCLs BSSH App](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-apps/dragen-germline-enrichment-from-bcls-bssh-app.md) - [DRAGEN Recipes](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes.md) - [DNA Germline Amplicon](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-germline-amplicon.md) - [DNA Germline Panel](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-germline-panel.md) - [DNA Germline Panel UMI](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-germline-panel-umi.md) - [DNA Germline WES](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-germline-wes.md) - [DNA Germline WES UMI](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-germline-wes-umi.md) - [DNA Germline WGS](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-germline-wgs.md) - [DNA Somatic Tumor-Normal Heme WGS](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-normal-heme-wgs.md) - [DNA Somatic Tumor-Normal MRD](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-normal-mrd.md) - [DNA Somatic Tumor-Normal Solid Panel](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-normal-solid-panel.md) - [DNA Somatic Tumor-Normal Solid Panel UMI](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-normal-solid-panel-umi.md) - [DNA Somatic Tumor-Normal Solid WES](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-normal-solid-wes.md) - [DNA Somatic Tumor-Normal Solid WES UMI](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-normal-solid-wes-umi.md) - [DNA Somatic Tumor-Normal Solid WGS](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-normal-solid-wgs.md) - [DNA Somatic Tumor-Normal Solid WGS UMI](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-normal-solid-wgs-umi.md) - [DNA Somatic Tumor-Only Heme WGS](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-only-heme-wgs.md) - [DNA Somatic Tumor-Only Solid Amplicon](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-only-solid-amplicon.md) - [DNA Somatic Tumor-Only Solid Panel](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-only-solid-panel.md) - [DNA Somatic Tumor-Only Solid Panel UMI](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-only-solid-panel-umi.md) - [DNA Somatic Tumor-Only Solid WES](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-only-solid-wes.md) - [DNA Somatic Tumor-Only Solid WES UMI](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-only-solid-wes-umi.md) - [DNA Somatic Tumor-Only Solid WGS](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-only-solid-wgs.md) - [DNA Somatic Tumor-Only Solid WGS UMI](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-only-solid-wgs-umi.md) - [DNA Somatic Tumor-Only ctDNA Amplicon](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-only-ctdna-amplicon.md) - [DNA Somatic Tumor-Only ctDNA Panel UMI](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/dna-somatic-tumor-only-ctdna-panel-umi.md) - [Illumina TruPath Genome WGS](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/illumina-trupath-genome-wgs.md) - [Illumina scRNA](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/illumina-scrna.md) - [Illumina scRNA Perturb seq](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/illumina-scrna-perturb-seq.md) - [Other scRNA prep](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/other-scrna-prep.md) - [RNA Amplicon](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/rna-amplicon.md) - [RNA Panel](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/rna-panel.md) - [RNA WTS](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/rna-wts.md) - [5 Base DNA Germline Panel](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/5-base-dna-germline-panel.md) - [5 Base DNA Germline Panel UMI](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/5-base-dna-germline-panel-umi.md) - [5 Base DNA Germline WGS](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/5-base-dna-germline-wgs.md) - [5 Base DNA Somatic Tumor-Normal Solid Panel](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/5-base-dna-somatic-tumor-normal-solid-panel.md) - [5 Base DNA Somatic Tumor-Normal Solid WGS](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/5-base-dna-somatic-tumor-normal-solid-wgs.md) - [5 Base DNA Somatic Tumor-Only Solid Panel](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/5-base-dna-somatic-tumor-only-solid-panel.md) - [5 Base DNA Somatic Tumor-Only Solid Panel UMI](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/5-base-dna-somatic-tumor-only-solid-panel-umi.md) - [5 Base DNA Somatic Tumor-Only Solid WGS](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/5-base-dna-somatic-tumor-only-solid-wgs.md) - [5 Base DNA Somatic Tumor-Only ctDNA Panel UMI](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-recipes/5-base-dna-somatic-tumor-only-ctdna-panel-umi.md) - [DRAGEN Reference Support](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-reference-support.md) - [Prepare a Reference Genome](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-reference-support/prepare-a-reference-genome.md) - [DRAGEN DNA Pipeline](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline.md) - [DNA Mapping](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/dna-map-align.md) - [Read Trimming](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/read-trimming.md) - [Sorting and Duplicate Marking](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/sort-dupmark.md) - [Small Variant Calling](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling.md) - [ROH Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling/roh-caller.md) - [B-Allele Frequency Output](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling/baf-output.md) - [Somatic Mode](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling/somatic-mode.md) - [Somatic ML for Small VC (Beta)](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling/somatic-mode/somatic-ml.md) - [Pedigree Analysis](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling/pedigree-analysis.md) - [De Novo Small Variant Filtering](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling/filtering.md) - [Autogenerated MD5SUM for VCF Files](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling/small-variant-calling2.md) - [Force Genotyping](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling/force-genotyping.md) - [Machine Learning for Variant Calling](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling/ml-for-vc.md) - [Evidence BAM](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling/evidence-bam.md) - [Mosaic Detection](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling/mosaic-detection.md) - [VCF Imputation](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling/vcf-imputation.md) - [Multi-Region Joint Detection](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling/multi-region-joint-detection.md) - [Small Variant Calling Metrics](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/small-variant-calling/small-variant-calling-metrics.md) - [Copy Number Variant Calling](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/cnv-overview.md) - [Germline](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/cnv-overview/cnv-germline.md) - [Somatic](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/cnv-overview/cnv-somatic.md) - [Reference](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/cnv-overview/cnv-reference.md) - [Repeat Expansion Detection](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/repeat-expansions.md) - [De Novo Repeat Expansion Detection](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/repeat-expansions/de-novo-str-detection.md) - [Targeted Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/targeted-caller.md) - [CYP2B6 Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/targeted-caller/cyp2b6-calling.md) - [CYP2D6 Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/targeted-caller/cyp2d6-calling.md) - [CYP21A2 Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/targeted-caller/cyp21a2-calling.md) - [GBA Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/targeted-caller/gba-calling.md) - [HBA Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/targeted-caller/hba-calling.md) - [LPA Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/targeted-caller/lpa-calling.md) - [Rh Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/targeted-caller/rh-calling.md) - [SMN Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/targeted-caller/smn-calling.md) - [Structural Variant Calling](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/sv-calling.md) - [Structural Variant De Novo Quality Scoring](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/sv-calling/sv-denovo-quality-scoring.md) - [Structural Variant IGV Tutorial](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/sv-calling/sv-igv-tutorial.md) - [Population Genotyping](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/iterative-gvcf-genotyper.md) - [Filter Duplicate Variants](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/variant-deduplication.md) - [Ploidy Calling](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/ploidy-calling.md) - [Ploidy Estimator](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/ploidy-calling/ploidy-estimator.md) - [Ploidy Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/ploidy-calling/ploidy-caller.md) - [Multi Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/multi-caller.md) - [HLA Typing](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/hla-typing.md) - [Biomarkers](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/biomarkers.md) - [Tumor Mutational Burden](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/biomarkers/biomarker-tmb.md) - [Microsatellite Instability](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/biomarkers/biomarker-msi.md) - [Homologous Recombination Deficiency](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/biomarkers/biomarker-hrd.md) - [Mutational Signatures](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/biomarkers/biomarker-mutational-signatures.md) - [BRCA Large Genomic Rearrangment](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/biomarkers/biomarker-brca-large-rearrangement.md) - [DRAGEN Fragmentomics](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/biomarkers/biomarker-fragmentomics.md) - [Downsampling](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/downsampling.md) - [Fractional (Raw Reads) Downsampling](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/downsampling/fractional-downsampler.md) - [Unique Molecular Identifiers](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/unique-molecular-identifiers.md) - [Indel Re-aligner (Beta)](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/indel-realigner.md) - [Star Allele Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/star-allele-caller.md) - [High Coverage Analysis](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/high-coverage.md) - [Population Haplotyping](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/population-haplotyping.md) - [DUX4 Rearrangement Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/dux4-rearrangement-caller.md) - [Oncovirus Detection](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-dna-pipeline/oncovirus-detection.md) - [DRAGEN RNA Pipeline](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-rna-pipeline.md) - [RNA Alignment](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-rna-pipeline/rna-alignment.md) - [Gene Fusion Detection](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-rna-pipeline/gene-fusion-detection.md) - [Gene Expression Quantification](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-rna-pipeline/gene-expression-quantification.md) - [RNA Variant Calling](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-rna-pipeline/rna-variant-calling.md) - [Splice Variant Caller](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-rna-pipeline/splice-variant-caller.md) - [DRAGEN Single Cell Pipeline](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-single-cell-pipeline.md) - [Illumina PIPseq scRNA](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-single-cell-pipeline/dragen-scrna-illumina.md) - [Other scRNA Prep](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-single-cell-pipeline/dragen-scrna-other.md) - [scATAC](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-single-cell-pipeline/dragen-scatac.md) - [Single-Cell Multiomics](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-single-cell-pipeline/dragen-multiomics.md) - [Illumina TruPath Genome Pipeline](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-trupath-pipeline.md) - [DRAGEN Methylation Pipeline](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-methylation-pipeline.md) - [Illumina 5-base Prep](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-methylation-pipeline/dragen-5base-pipeline.md) - [Other Methylation Prep](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-methylation-pipeline/dragen-methylation-pipeline.md) - [DRAGEN MRD Pipeline](https://help.dragen.illumina.com/product-guides/dragen-v4.5/mrd.md) - [DRAGEN Amplicon Pipeline](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-amplicon-pipeline.md) - [DRAGEN 16S Pipeline](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-16s-pipeline.md) - [16S Pipeline Pre-Built Database](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-16s-pipeline/dragen-16s-db.md) - [16S Custom Database](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-16s-pipeline/dragen-16s-custom-db.md) - [16S Sample JSON](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-16s-pipeline/report-json-format.md) - [DRAGEN K-mer Classifier](https://help.dragen.illumina.com/product-guides/dragen-v4.5/kmer-classifier.md) - [Prebuilt K-mer Databases](https://help.dragen.illumina.com/product-guides/dragen-v4.5/kmer-classifier/prebuilt-kmer-dbs.md) - [K-mer Classifier Database Builder](https://help.dragen.illumina.com/product-guides/dragen-v4.5/kmer-classifier/kmer-class-db-builder.md) - [Microbial Binner Database](https://help.dragen.illumina.com/product-guides/dragen-v4.5/kmer-classifier/microbial-binner.md) - [DRAGEN Microbial Enrichment Plus](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dme-plus-overview.md) - [Reference Databases](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dme-plus-overview/dme-plus-databases.md) - [Custom Database](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dme-plus-overview/dme-plus-custom-database.md) - [Output](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dme-plus-overview/dme-plus-output.md) - [BCL conversion](https://help.dragen.illumina.com/product-guides/dragen-v4.5/bcl-conversion.md) - [DRAGEN QC Metrics](https://help.dragen.illumina.com/product-guides/dragen-v4.5/qc-metrics-reporting.md) - [Minimal Checklist](https://help.dragen.illumina.com/product-guides/dragen-v4.5/qc-metrics-reporting/minimal_checklist.md) - [Contamination Detection](https://help.dragen.illumina.com/product-guides/dragen-v4.5/qc-metrics-reporting/contamination-detection.md) - [FastQC](https://help.dragen.illumina.com/product-guides/dragen-v4.5/qc-metrics-reporting/dragen-fastqc.md) - [CheckFingerprint](https://help.dragen.illumina.com/product-guides/dragen-v4.5/qc-metrics-reporting/checkfingerprint.md) - [JSON Metrics Reporting](https://help.dragen.illumina.com/product-guides/dragen-v4.5/qc-metrics-reporting/json-metrics-reporting.md) - [Illumina Connected Annotations](https://help.dragen.illumina.com/product-guides/dragen-v4.5/nirvana.md) - [ORA Compression](https://help.dragen.illumina.com/product-guides/dragen-v4.5/ora-compression.md) - [Command Line Options](https://help.dragen.illumina.com/product-guides/dragen-v4.5/command-line-options.md) - [Docker Requirements](https://help.dragen.illumina.com/product-guides/dragen-v4.5/command-line-options/docker-requirements.md) - [DRAGEN Reports](https://help.dragen.illumina.com/product-guides/dragen-v4.5/dragen-reports.md) - [Tools and Utilities](https://help.dragen.illumina.com/product-guides/dragen-v4.5/tools-and-utilities.md) --- # Agent Instructions: Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question. Perform an HTTP GET request on the current page URL with the `ask` query parameter: ``` GET https://help.dragen.illumina.com/product-guides.md?ask= ``` The question should be specific, self-contained, and written in natural language. The response will contain a direct answer to the question and relevant excerpts and sources from the documentation. Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.